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What is ECS?

Human Endocannabinoid System: why Path of Purity’s superior Bioavailability and Absorption Matter

In our view any discussion about why an individual should choose to take Path of Purity or any CBD Product should begin with an understanding of their Endocannabinoid System, as follows.

The Endocannabinoid System (ECS) manages and regulates many of our body's natural functions including:

  • Mood
  • Cognition
  • Memory
  • Motor Coordination/Control
  • Appetite
  • Pain Perception
  • Immune response
  • Temperature
  • Reproduction
  • Sleep
  • Bone Development

The scope and complexity of these functions, makes ECS a bridge between mind and body and thereby a foundation of emotional and physical performance and health - or conversely (if our ECS is deficient) decline and illness.

What the Endocannabinoid System Does

If you think about it, our Endocannabinoid System may well be our body's most powerful and vital healing and quality of life resource. This is because ECS helps us maintain a stable internal environment despite changes and challenges faced in our external environment. This requires ECS to manage a complex process of neuroprotection, stress recovery, immune balance, and energy regulation (using our body's most complex signalling and neurotransmitter system to deliver instantaneous cellular communication and feedback).

To effect this, the Endocannabinoid System is comprised of a network of two (2) specialized types of Receptors located throughout our body:

  • CB1 receptors found primarily in the brain, nervous system, connective tissues, gonads, glands, and organs; and
  • CB2 receptors, which are primarily found in the immune system as well as the spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands, and reproductive organs.

The following chart shows the locations of Endocannabinoid System Receptors throughout the body in vital organs and systems:

ECS chart

CB1 and CB2 receptors are embedded in cell membranes and many tissues contain both CB1 and CB2 receptors. Endocannabinoid System receptors are the most abundant receptors found in the brain. Collectively ECS uses this network of receptors much like the "conductor of an orchestra" - signalling receptors from our brain, to our organs, to our connective tissues, to our glands and to our immune cells to adjust to (even) subtle changes in biochemical cues in fluids surrounding each cell.

Whereas a conductor uses a "baton" to signal orchestra members to use different instruments and different movements toward the common goal of producing a great, harmonized sound, ECS uses Endocannabinoids (which it manufactures on demand as needed) to direct different cell types to perform different actions toward the common goal of promoting and regulating homeostasis.

Each Endocannabinoid acts like a "key within a lock" when it interacts with a CB1 or CB2 receptor - causing cells to harmonize and collaborate with other cells toward our body's best outcome.

For example, when we are injured our body's best outcome is to minimize pain and damage caused by the injury while facilitating full recovery as promptly as possible. ECS contributes to this outcome by releasing Endocannabinoids that signal 3 different cell types to undertake 3 different actions:

  1. the injured tissue is "told" to reduce the release of activators and sensitizers;
  2. nerve cells are "told' to stabilize to prevent excessive firing, and
  3. nearby immune cells are "told" to calm to prevent release of pro-inflammatory substances.

This injury example illustrates unique capabilities of Endocannabinoids and our ECS:

  1. Endocannabinoids communicate with and simultaneously coordinate the actions of different cell types - causing them to work collaboratively.
  2. Endocannabinoids are the only Neurotransmitter able to communicate backwards: Neurotransmitters normally flow from presynaptic neurons to postsynaptic neurons. Going in the opposite direction enables Endocannabinoids to deliver feedback to a presynaptic cell. This is fundamental to homeostasis since if a neuron is firing messages too quickly, then endocannabinoids instruct it to slow down by traveling upstream and activating presynaptic CB1 receptors.

What harnessing the power of ECS may enable

Since its discovery in the 1980s, the Endocannabinoid System has been the subject of many scientific studies all over the World to help evaluate ECS potential to positively impact a wide range of health conditions as well as their underlying disease causes and risk factors. This is hardly surprising since (to reiterate) our ECS affects every MAJOR organ and system in our body as illustrated in this more simplified view:

ECS Receptors

Among the most comprehensive studies we found is: The Endocannabinoid System as an Emerging Target of Pharmacotherapy by Drs. Pal Pacher, Sandor Batkai and George Kunos that was published in 2006. PAL PACHER, SANDOR BATKAI, and GEORGE KUNOS Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, Pharmacol Rev. 2006 September ; 58(3): 389-462

Among Drs. Pacher, Batkai and Kunos’s conclusions was the following overview:
In the past decade, the endocannabinoid system has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs. Modulating the activity of the endocannabinoid system turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson's and Huntington's disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few.

Drs. Pacher, Batkai and Kunos’s observations resulted from their compilation of a highly-detailed and highly-technical compendium of studies describing how helping the Endocannabinoid System (ECS) manage and regulate the vital body functions it manages and regulates could, in turn, affect a wide range of conditions as follows:

  • A. Diseases of Energy Metabolism (Page 9)
    1. Appetite Regulation (Page 9)
    2. Peripheral Energy Metabolism (Page 12)
    3. Obesity and Metabolic Abnormalities (Page 15)
    4. Cachexia and Anorexia (Page 17)
  • B. Pain and Inflammation (Page 18)
  • C. Central Nervous System Disorders (Page 21)
    1. Neurotoxicity and Neuro-trauma (Page 21)
    2. Stroke (Page 23)
    3. Multiple Sclerosis and Spinal Cord Injury (Page 24)
    4. Movement Disorders (Basal Ganglia Disorders) Page 28
      • Parkinson's Disease (Page 28)
      • Huntington's Disease (Page 30)
      • Tourette's Syndrome (Page 31)
    5. Amyotrophic Lateral Sclerosis (ALS) Page 31
    6. Alzheimer's (Page 32)
    7. Epilepsy (Page 33)
    8. Mental Disorders (Page 34)
      • Schizophrenia (Page 35)
      • Anxiety and Depression (Page 36)
    9. Insomnia (Page 38)
    10. Nausea and Emesis (Vomiting) Page 39
    11. Drug addiction and Alcohol Disorders (Page 40)
      • Opiates (Page 41)
      • Nicotine (Page 42)
      • Cocaine (Page 42)
      • Alcohol (Page 43)
      • Psychostimulants (Page 44)
  • D. Cardiovascular and Respiratory Disorders (Page 44)
    1. Hypertension (Page 46)
    2. Circulatory Shock (Hemorrhagic, Cardiogenic, Endotoxic) Page 47
    3. Myocardial Reperfusion Injury (Page 49)
    4. Atherosclerosis (Page 50)
    5. Asthma (Page 50)
  • E. Eye Disorders (Glaucoma and Retinopathy) (Page 51)
  • F. Cancer (Page 53)
  • G. Gastrointestinal and Liver (Page 55)
    1. Inflammatory Bowel Syndrome (Page 56)
    2. Acute and Chronic Liver Disease (Hepat and Liver Cirrhosis) Page 57
  • H. Musculoskeletal Disorders (Page 59)
    1. Arthritis (Page 59)
    2. Osteoporosis (Page 60)
  • I. Reproduction (Page 60)

PoP grew from the shared intention of a group of scientists, herbalists and business partners to improve the lives of millions of people by making the well-documented benefits of CBD available at the best possible quality, price and overall value.

The result of that effort IS Path of Purity!
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This product has not been evaluated by the FDA and is NOT intended to treat, prevent, or cure any condition, illness or disease. As with any dietary herb, oil, or supplement, we recommend you consult your doctor before using this product. If you are pregnant, nursing, anticipate surgery, take medication on a regular basis, or are otherwise under medical supervision, please abstain from using this product. Athletes, and all others are cautioned to consult the specific rules of their sport or workplace before taking Path of Purity or any Hemp product.

Path of Purity, LLC does not diagnose, treat, nor cure any illness or medical condition. Our services promote wellness and improved athletic performance; results vary. Readers and users alike are advised to use the information presented under the supervision of their Family Doctor and/or other Health Professionals whom they rely upon.

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